Together, we can accomplish more.

We are building a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360™ precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases.

We are led by a highly talented executive team with proven experience creating best places to work. We are driven to help patients in need, foster personal and professional growth, unlock our team potential, and to deliver exceptional results.

We offer competitive benefits, pay, time off, and perks!

If you have a passion for being a market leader, discovering and developing disruptive therapies, improving the lives of patients, love what you do and want to help us build a next-generation and best places to work company—we want to hear from you.

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Our Values

Mirador’s commitment to values of trust, ambition, collaboration, integrity, and excellence shapes our culture of teamwork, innovation, and relentless pursuit of developing transformative precision therapies for patients with immune-mediated diseases.

TRUST

  • We trust each other, believing that we all have best intentions and are delivering our part of the collective vision to improve the lives of patients with immune-mediated diseases.
  • We hold each other accountable, trusting that we have each other’s backs.
  • We trust in the process and feel empowered to address challenges knowing they are part of how we win.

AMBITION

  • We think creatively, experiment fearlessly, and develop groundbreaking ideas that benefit our patients.
  • Our ambition fuels our moonshot thinking and relentless pursuit of our goals.
  • We are empowered to challenge the status quo and seek new solutions to make what seems impossible a reality.

COLLABORATION

  • We show up every day knowing that every team member brings unique value and perspective to our shared vision.
  • We know that our team output is stronger than the sum of our individual capabilities.
  • We encourage active listening, open-mindedness, and constructive feedback across all levels of the organization.

INTEGRITY

  • We support each other to make the right decisions and do the right thing.
  • We have a commitment to ethical conduct in all aspects of our business.
  • Our truth is driven by science and data, which we follow no matter where it leads.

EXCELLENCE

  • We expect excellence in all we do.
  • We leverage diverse skills and perspectives to achieve excellence in our shared goals.
  • Individual excellence is a given; team excellence is our competitive advantage.

Positions available at Mirador Therapeutics:

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a motivated, versatile, detail-oriented Research Associate to support internal discovery efforts with the Immunology team. This individual will have a background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Key Duties and Responsibilities

  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development
  • Work on preclinical and IND-enabling in vitro studies
  • Analyze, critically interpret data and share results to project teams as required
  • Keep meticulous records of experiments performed and maintain ELN entries
  • Work collaborative with other scientists in the group in a highly matrixed lab environment

Education and Experience

  • Bachelor’s degree in Biology, Biochemistry or Cell Biology
  • Background in Immunology is a plus
  • 2 years or more of biotech or pharmaceutical industry experience

Skills and Abilities

  • Independent self-motivated life scientist that can generate scientific questions and design experiments to address them
  • Energetic, curious and rigorous
  • Excellent problem-solving and organizational skills
  • Strong interpersonal and communication skills including presenting data to all levels of the organization
  • Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis
  • Ability to work in fast-paced and matrix environment to meet project goals
  • Proficiency in data analysis using Excel, GraphPad Prism, Flow Jo is required

The expected base pay range for this position is $75,000 – $100,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA preferred or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

The Director, CMC will lead biologics development and manufacturing to deliver clinical trial supplies across multiple clinical studies.

Responsible for directing technical aspects of the biologics process development and manufacturing activities at contract manufacturers organizations (CMOs) and consultants including development, scale-up, technical transfers, validation, delivery of launch supplies.  Daily activities such as on-going manufacturing support, process improvements, analytical development determination and development, and technical guidance both internally and externally.  Responsible for coordinating manufacturing, packaging and distribution of clinical trial materials and set up of drug distribution through IVRS/IWRS.

Support the CMC team in writing Quality sections for global regulatory filings and also provide support of business development activities and due diligences.

Responsibilities

  • Responsible for leading and overseeing all aspects of the manufacture of products at CROs and/or CMOs around the world and ensures adherence to project timelines to support clinical and/or commercial supply in line with business objectives.
  • Reviews and provides oversight of all documentation related to the production of the product including but not limited to:development, scale-up and validation protocols/reports batch records, deviations, process excursions, analytical methods, protocols and reports.
  • Contributes in setting up specifications for starting materials, intermediates and drug substance and product.In conjunction with the CMO and other groups adjudicates deviations and leads or conducts a root cause analysis and implement proposed corrective actions at CRO/CMO.

Experience and Qualifications

  • PhD highly preferred with a minimum of 10 years of experience in biologics development, pilot plant, biologics development and manufacturing operations for pharmaceutical APIs (drug substances).
  • Bachelor’s or Master’s degree in Biology, Microbiology, Chemical Engineering or related field with a minimum of 12 years of experience.
  • Demonstrated scientific knowledge relevant to development and manufacture of biologic drug substances and products with understanding of analytical techniques required for phase appropriate development.
  • Must have demonstrated experience in managing and influencing diverse project activities with third party manufacturing facilities at different geographical locations.
  • Strong project management experience with cross-functional team leadership and participation skills.
  • Requires strong understanding of technology transfer; cGMPs, FDA, EU, ICH guidelines; as well as CMC content of regulatory submissions.

Essential Skills and Abilities

  • Self-starter who can work independently and can prioritize tasks.
  • Strong communication skills, (both written and oral) including presentations to senior management and external audiences and experts.
  • Strong understanding and working knowledge of cGMPs for biologics pharmaceutical development and operations.
  • Leadership capabilities for cross functional teams.
  • Ability to work across locations and time zones; must be able to travel approximately 25% including international travel.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

As Scientific Data Curation Engineer you will drive the delivery of high-quality clinical and omic datasets to the world-class Mirador360 platform to accelerate the work of Mirador’s Precision Analytics team. The Scientific Data Engineer conducts acquisition and disposition activities related to biomedical data collected from various sources, in diverse formats, and using different modalities.  You will support the specification, acquisition, organization, QC, annotation, and harmonization of data using specified standards and ensure data are stored in defined locations within system.  You will drive execution and adhere to timelines for both vendor-managed and hands-on data curation projects.  As the company’s data curation expert, you will act as a liaison and consultant on best practices, principles and processes required to leverage best in class data curation capabilities and technologies.

Responsibilities

  • Clean, harmonize, curate and catalog clinical, omics, and other data and metadata according to various data practices and standards
  • Align data to ontologies/vocabularies
  • Collaborate with cross-functional team members to define and implement new data standards, data models, terminologies, and ontologies and to provide input on automated omics processing pipelines
  • Collaborate with cross-functional team members to plan which data will be loaded for what purpose and define the required quality control steps
  • Engage data providers to manage acquisition of electronic datasets
  • Understand the context underlying each data type targeted for acquisition to ensure that the data quality is fit for purpose
  • Support the development and documentation of metadata standards for sharing datasets under the Findability Accessibility Interoperability and Reusability (FAIR) guiding principles
  • Streamline data curation processes and implement new methods and pipelines
  • Assess transferred data for quality and conformance and resolve any queries/issues with data provider
  • Work with team members in the development and implementation of data standards and processes to ensure data quality
  • Communicate strategies, ideas, goals, and progress to the team
  • Collaborate closely with Precision Analytics team

Experience and Qualifications

  • Master’s degree with at least 3 years experience OR a Bachelor’s degree with at least 5 years experience in the data science field in biotech, diagnostics or pharma industry experience
  • Experience organizing, analyzing and visualizing common biomedical data types derived from disease model systems and patients
  • Experience with genetics, gene expression and other omic data is preferred
  • Experience in a scripting language (e.g. bash, R or python)
  • Experience working with external vendors and internal stakeholders to refine deliverables and timelines along organizational priorities
  • Knowledge of CDISC data standards, ICH-GCP, Awareness of Patient-level Data Access principles, and experience in regulated environments
  • Knowledge of basic biological principles and the pharmaceutical development process (including clinical trials, patient level datasets and study documentation)
  • Deep understanding of clinical and omics data, data curation methodologies, and a commitment to maintaining data accuracy and integrity
  • Systematic, structured, and pragmatic approach to tasks, with good attention to detail
  • Ability to effectively manage multiple requests and priorities

Essential Skills and Abilities

  • Clear and proactive communication skills and the ability to communicate appropriately with corporate executives, technical and non-technical teams
  • Strong influencing and reasoning skills; good at conflict resolution and consensus building
  • Self-motivated and collaborative with excellent planning, independent problem-solving and organizational skills
  • Ability to engage constructively with peers and technical leads to communicate the technical approach, trade-offs, and technical decisions
  • Entrepreneurial, thrives in a fast-paced, smaller-company environment

The expected base pay range for this position is $100,000 -$175,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Director, Program Management, experienced in managing programs and project teams from discovery into IND and early clinical development.

The position reports to the VP, Project Management.

Responsibilities

  • Responsible for effectively leading early discovery-stage portfolio project teams
  • Expertly listen to input from subject matter experts and distill critical information in a manner that enables project teams to formulate the optimal strategy for the program
  • Work as a partner to the project team leader to define project plans and timelines, track progress across functions and enable the project team to execute on the project plan
  • Manage the integrated project plans and track progress on cross-functional deliverables
  • Lead cross-functional scenario planning to inform the overall project plan
  • Close collaborator of project team members providing PM support to functions as needed, including management of CRO activities and timelines
  • Ensure projects achieve key deliverables and progress toward milestones according to timeline
  • Run project team meetings, write minutes, record project progress, follow up on action items
  • Provide regular project updates and communicate timelines to executive team as needed

Experience and Qualifications

  • Bachelor’s degree required. Advanced degree (MS or PhD) in life sciences or other discipline related to drug development strongly preferred
  • PhD with minimum of 10 years or MS with a minimum of 12 years combined scientific and project management experience
  • Minimum of 7 years of relevant biotech or pharmaceutical industry experience
  • At least 3-5 years in program/project management at a pharma/biotech company with strong understanding of other functions relevant to the position which may include Discovery, Translational, Clinical, Nonclinical, CMC and Regulatory
  • Proven ability to successfully manage cross functional teams to drive programs forward to achieve defined goals; ability to articulate project objectives and priorities
  • Experience leading cross functional activities through IND submission required
  • Deep understanding of necessary deliverables to enable successful drug discovery and development from identification of drug candidate through to early clinical development
  • Experienced in managing CROs and demonstrated ability to ensure CROs deliver against commitments
  • Adept at managing multiple projects/tasks simultaneously, switching between tasks quickly, juggling competing priorities
  • Excellent problem solver and critical thinker with ability to apply a broad but integrated perspective to quickly and effectively distill information and assess impact on overall project plan and timeline, including the identification of potential issues and risk mitigation strategies
  • Scientific curiosity, effective communicator, high level of scientific and operational skills, and emotional intelligence
  • A hands-on, entrepreneurial style with a sense of urgency, a bias toward action, comfort with calculated risk, and the ability to analyze situations rapidly to present scenarios that enable team decisions
  • The requisite scientific acumen and communication skills to influence and collaborate with key scientific, regulatory, and business leaders
  • Sound strategic, clinical, technical, operational, and ethical judgment with uncompromising integrity

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Executive Director, Machine Learning to lead the development and application strategy of models leveraging multi-modal data (genetics, omics, EHR/text) to obtain new insights and therapeutic hypotheses.  In this position, the individual will lead a team of machine learning scientists and software engineers to build, train, test, and maintain predictive, interpretable, and generalizable data models, including large language models (LLMs). The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Responsibilities

  • Lead development and strategic deployment of machine learning and AI models across Mirador’s infrastructure to derive new insights for R&D, commercial and clinical teams
  • Drive implementation of predictive models combining clinical, genetic, imaging, and circulating biomarkers to illuminate biological mechanisms and enable patient stratification and indication expansion.
  • Design, develop, and fine-tune large-scale neural network models, with a strong emphasis on language models.
  • Explore state-of-the-art techniques in NLP, transfer learning, and generative AI to enhance our capabilities.
  • Participate in and oversight of scientific report writing. Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Mentor junior members of the team and set goals, priorities and evaluation criteria for the team
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Experience and Qualifications

  • Ph.D. in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • 14 or more years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues.

The expected base pay range for this position is $225,000 – $325,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Associate Director, AI to report to the Executive Director, AI & Machine Learning and collaborate on development of deep neural networks (DNNs) and large language models (LLMs) leveraging multi-modal data (genetics, omics, EHR/text) to drive new insights and therapeutic hypotheses.  In this position, the individual will be responsible to build, train, test, and maintain predictive, interpretable, and generalizable data models. The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Key Duties and Responsibilities

  • Design, develop, and fine-tune large-scale neural network models, with a strong emphasis on language models.
  • Explore state-of-the-art techniques in NLP, transfer learning, and generative AI to enhance our capabilities.
  • Participate in and oversight of scientific report writing. Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Education and Experience

  • PhD in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • Minimum of 7 years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues.

The expected base pay range for this position is $125,000 – $240,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Associate Director, Machine Learning to report to the Executive Director, Machine Learning and collaborate on development of statistical models leveraging multi-modal data (genetics, omics, EHR/text) to drive new insights and therapeutic hypotheses.  In this position, the individual will be responsible to build, train, test, and maintain predictive, interpretable, and generalizable data models. The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Responsibilities

  • Design and perform analyses to infer causal mechanisms driving inflammatory mechanisms integrating data collected from pre-clinical models and human data sets.
  • Drive implementation of predictive models combining clinical, genetic, imaging, and circulating biomarkers to illuminate biological mechanisms and enable patient stratification and indication expansion.
  • Participate in and oversight of scientific report writing.Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Experience and Qualifications

  • PhD in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • Minimum of 7 years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues. 

The expected base pay range for this position is $125,000 – $240,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Principal Scientist with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 8 years or more of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associates/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Director with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Experience and Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 12 or more years of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associate/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Associate Director with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Experience and Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 10 or more years of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associate/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a motivated, versatile, detail-oriented Senior Associate Scientist / Scientist to join the Immunology Translational Team. The focus will be on preclinical and IND-enabling in vitro studies. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment.

Key Duties and Responsibilities

  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development
  • Work on preclinical and IND-enabling in vitro studies
  • Analyze, critically interpret data and share results to project teams as required
  • Keep meticulous records of experiments performed and maintain ELN entries
  • Work collaborative with other scientists in the group in a highly matrixed lab environment

Education and Experience

  • Sr Associate Scientist requires: Bachelor’s degree with 6 or more years experience or Master’s degree with 2 or more years experience
  • Scientist requires: Bachelor’s degree with 8 or more years experience or Master’s degree with 6 or more years experience
  • Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation are required
  • Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required
  • Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets.
  • Experience with cell-based assays including primary cell and reporter cell assays
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is required
  • Experience with Western Blots for samples generated from cell pellets and tissue
  • Experience with protein quantification techniques from tissue samples
  • Experience with tissue explants and organoid systems is a plus

Skills and Abilities

  • Independent self-motivated life scientist that can generate scientific questions and design experiments to address them
  • Energetic, curious and rigorous
  • Excellent problem-solving and organizational skills
  • Strong interpersonal and communication skills including presenting data to all levels of the organization
  • Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis
  • Ability to work in fast-paced and matrix environment to meet project goals
  • Proficiency in data analysis using Excel, GraphPad Prism, Flow Jo is required

The expected base pay range for this position is $75,000 – $175,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a highly motivated protein engineer to join the biotherapeutics discovery group. The candidate must have demonstrable experience with antibody discovery and protein engineering programs in a biologics discovery setting.

Responsibilities

  • Expertise in protein and antibody engineering in the discovery and preclinical development of biotherapeutic candidates. Assist in evaluating new technologies to stay at the cutting edge of biologics discovery, production, and characterization.
  • Play a key role in assessing protein structure and function as applied toward the evaluation of biologics for protein design and engineering.
  • Present your findings and ideas to an interdisciplinary team with a wide range of technical backgrounds.

Qualifications

  • PhD in Molecular Biology, Structural Biology, Biophysics, Biochemistry, or related disciplines and 8 years or more of experience in the biotechnology or pharmaceutical industry
  • Manage all aspects of protein and antibody expression, purification, and characterization to support the preclinical discovery and development efforts of the biotherapeutics group.
  • Experience managing external CROs and vendors for protein engineering work.
  • Demonstrable experience in antibody discovery, antibody engineering, or the engineering of other proteins.
  • Familiarity with various antibody formats and scaffolds including, but not limited to fusion proteins, bi-specific antibodies, single-domain antibodies (VHH), and bi-paratopic antibodies.
  • Experience in mammalian cell culture and protein expression systems.
  • Self-starter, strong collaborative skills working in cross-functional teams and a start-up environment.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.  

Summary

We seek a motivated, detail-oriented Director, Discovery Immunology with strong background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

The role will require deep scientific and therapeutic-area expertise in Discovery Immunology, thorough familiarity and experience with the principles of drug development to ensure compound transition along the pipeline, management experience, and importantly the ability to work with ambiguity and embrace uncertainty. The role will demand critical, timely, independent decision making and requires a high degree of autonomy.

This leader must have scientific excellence in Immunology with a rich understanding of drug development, leadership, recruitment capabilities, management skills to direct a group of individuals, and excellent communication and collaboration skills to deliver on the therapeutic area strategy.

Qualifications

  • PhD or equivalent post-graduate degree in Immunology or related field with 12 years or more of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in Discovery Immunology required.
  • Prior people management experience.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Experience in early drug discovery with proven leadership of preclinical development of therapeutic project(s) and clinical candidate selection is a requirement.
  • Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards, and outstanding written and verbal communication skills.
  • A desire to be part of a highly innovative, dynamic, and growing company aimed at developing novel therapeutics for patients.
  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables, delivering clinical candidates into development.
  • Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators.
  • Proven track record of advancing programs through discovery, IND-enabling studies, and IND filing.
  • Ability to build strong relationships with key stakeholders.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Principal Scientist/Associate Director, Discovery Immunology with strong background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

The role will require deep scientific and therapeutic-area expertise in Discovery Immunology, thorough familiarity and experience with the principles of drug development to ensure compound transition along the pipeline, management experience, and importantly the ability to work with ambiguity and embrace uncertainty. The role will demand critical, timely, independent decision making and requires a high degree of autonomy.

This leader must have scientific excellence in Immunology with a rich understanding of drug development, leadership, recruitment capabilities, management skills to direct a group of individuals, and excellent communication and collaboration skills to deliver on the therapeutic area strategy.

Qualifications

  • Associate Director: PhD or equivalent post-graduate degree in Immunology or related field with 10 years or more of experience in academia and industry, preferably in the field of auto-immune diseases. Principal Scientist: PhD or equivalent post-graduate degree in Immunology or related field with 8 years or more of experience in academia and industry.
  • Prior industry experience in Discovery Immunology required.
  • Prior people management experience.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Experience in early drug discovery with proven leadership of preclinical development of therapeutic project(s) and clinical candidate selection is a requirement.
  • Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards, and outstanding written and verbal communication skills.
  • A desire to be part of a highly innovative, dynamic, and growing company aimed at developing novel therapeutics for patients.
  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables, delivering clinical candidates into development.
  • Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators.
  • Proven track record of advancing programs through discovery, IND-enabling studies, and IND filing.
  • Ability to build strong relationships with key stakeholders.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

 Summary
We are seeking a highly motivated hands-on physician leader to serve as Vice President, Clinical Development who will lead a portfolio of the company’s clinical studies for current and future indications.

This position will play a key role in driving the execution of studies from indication selection, protocol concept, design, and conduct, to final report including interpretation of clinical data, and preparation of documents for filing with regulatory agencies.

As a subject matter expert, the incumbent will work with key stakeholders on the development of clinical protocols to support the company’s product strategy, data collection and management, and final reports development in compliance with appropriate standard operating procedures, and regulatory and medical standards. This position interacts with various groups within the company and externally to the business to ensure alignment and oversee clinical research activities.

Responsibilities

  • Provide clinical leadership of trial execution from first-in-human through registrational studies.
  • Provide clinical leadership in the conduct of clinical activities including recruitment, data review, analysis, and reporting that conforms to the highest ethical, safety and quality standards and in compliance with GCP and regulatory standards.
  • Attend and present at investigator meetings and site initiation visits as applicable.
  • Provide clinical leadership in the preparation of Clinical Study Reports, Annual Reports and other safety reports, Health Authority pre-meeting packages, Investigator Brochures and other periodic clinical reports.
  • Collaborating with cross-functional groups to provide input in publication strategy including active participation in authoring, preparation, and review of manuscripts, conference abstracts and presentations, and other external presentations of clinical data.
  • Partner with R&D to provide clinical perspective to target selection and development strategy. Offer clinical input/direction on early-stage, pre-clinical projects.
  • Remain current on the therapeutic landscape in the relevant therapeutic areas through review of the scientific literature, interactions with key opinion leaders and other external experts, and attendance at relevant scientific meetings, in order to provide input and guidance for the strategic direction of the company.
  • Partner with Medical Affairs on the overall strategy for Target Product Profiles, clinical trial design, and ensuring dissemination of medically accurate information related to the company’s product candidates.

Qualifications

  • MD degree or equivalent is required. Board Certification or Board Eligibility in internal medicine, subspecialty training or experience in drug development in pulmonology, gastroenterology, or dermatology medicine is highly desirable.
  • 10 years or more of experience in pharmaceutical clinical drug development in industry including protocol development; study initiation and follow-up; IRB/EC submissions and interactions; review of clinical study data listings; review and/or preparation of clinical study reports.
  • The candidate should have experience with U.S. and European Health Authority interactions and have experience with submissions of clinical regulatory documents.
  • A clinical background that includes experience in pulmonology, gastroenterology, or dermatology a plus. Experience working across broad disease areas with an aptitude for learning equally desired.
  • Exceptional execution, and implementation of practices and initiatives to ensure timelines and budgets are met.
  • The ability to build and maintain excellent interpersonal relationships, both within and outside the company, at all levels.
  • A hands-on, entrepreneurial style with a sense of urgency, a bias toward action, comfort with calculated risk, and the ability to analyze situations rapidly and make prudent decisions.
  • Engaged, hands-on, independent, and goal-oriented mentality; willingness to work in a highly dynamic work environment and embrace uncertainty.

Skills and Abilities

  • Highly dynamic work environment and embrace uncertainty.
  • Ability to multi-task and willingness to flexibly contribute simultaneously in multiple facets of drug development; willingness to learn new therapeutic areas.
  • Self-motivated; strong commitment to follow up on tasks and action items; organizational, analytical, and problem-solving skills; risk identification and management; creative and innovative thinking all highly desirable.
  • Strong ability to work within and lead and motivate a cross-functional matrixed team.
  • The requisite scientific acumen and communication skills to influence and collaborate with key scientific, regulatory, and business leaders.
  • Sound strategic, clinical, technical, operational, and ethical judgment with uncompromising integrity.

The expected base pay range for this position is $250,000 – $400,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

Mirador provides equal employment opportunities to all employees and applicants for employment without regard to race, religion, religious creed (including religious dress and grooming practices), color, national origin, citizenship, ancestry, physical disability, mental disability, legally-protected medical condition or information (including genetic information), marital or domestic partner status, sex (including pregnancy, perceived pregnancy, childbirth, breastfeeding, or related medical conditions), gender, gender identity, gender expression, age (40 years and over), sexual orientation, military and/or veteran status, protected medical leaves (including but not limited to requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), requesting a reasonable accommodation on the basis of disability or bona fide religious belief or practice, victims of domestic violence, sexual assault, or stalking, political affiliation, and any other status protected by federal, state, or local law.

Equal employment opportunity applies to all terms and conditions of employment, including hiring, placement, promotion, discipline, termination, layoff, transfer, leave of absence, compensation, employee benefits and application of policies and training. It is the responsibility of every manager and employee to conscientiously follow this policy. Any employee having any questions regarding this policy should discuss them with Human Resources.

Thank you for your interest in Mirador Therapeutics and our recruitment opportunities. Recruiting and employment are managed through the Human Resources Department. Mirador requires that a signed agreement be in place prior to the presentation of any candidates. We ask that recruiters and agencies do not contact or solicit employees or managers in an attempt to present candidates. The company will not be obligated or responsible for any requested fees to candidate resumes that are unsolicited and or submitted to hiring managers without a written agreement signed by the Chief People Officer of Mirador. Thank you.