Together, we can accomplish more.

We are building a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360™ precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases.

We are led by a highly talented executive team with proven experience creating best places to work. We are driven to help patients in need, foster personal and professional growth, unlock our team potential, and to deliver exceptional results.

We offer competitive benefits, pay, time off, and perks!

If you have a passion for being a market leader, discovering and developing disruptive therapies, improving the lives of patients, love what you do and want to help us build a next-generation and best places to work company—we want to hear from you.

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Our Values

Mirador’s commitment to values of trust, ambition, collaboration, integrity, and excellence shapes our culture of teamwork, innovation, and relentless pursuit of developing transformative precision therapies for patients with immune-mediated diseases.

TRUST

  • We trust each other, believing that we all have best intentions and are delivering our part of the collective vision to improve the lives of patients with immune-mediated diseases.
  • We hold each other accountable, trusting that we have each other’s backs.
  • We trust in the process and feel empowered to address challenges knowing they are part of how we win.

AMBITION

  • We think creatively, experiment fearlessly, and develop groundbreaking ideas that benefit our patients.
  • Our ambition fuels our moonshot thinking and relentless pursuit of our goals.
  • We are empowered to challenge the status quo and seek new solutions to make what seems impossible a reality.

COLLABORATION

  • We show up every day knowing that every team member brings unique value and perspective to our shared vision.
  • We know that our team output is stronger than the sum of our individual capabilities.
  • We encourage active listening, open-mindedness, and constructive feedback across all levels of the organization.

INTEGRITY

  • We support each other to make the right decisions and do the right thing.
  • We have a commitment to ethical conduct in all aspects of our business.
  • Our truth is driven by science and data, which we follow no matter where it leads.

EXCELLENCE

  • We expect excellence in all we do.
  • We leverage diverse skills and perspectives to achieve excellence in our shared goals.
  • Individual excellence is a given; team excellence is our competitive advantage.

Positions available at Mirador Therapeutics:

(San Diego, CA or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Executive Director, Machine Learning to lead the development and application strategy of models leveraging multi-modal data (genetics, omics, EHR/text) to obtain new insights and therapeutic hypotheses.  In this position, the individual will lead a team of machine learning scientists and software engineers to build, train, test, and maintain predictive, interpretable, and generalizable data models, including large language models (LLMs). The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Responsibilities

  • Lead development and strategic deployment of machine learning and AI models across Mirador’s infrastructure to derive new insights for R&D, commercial and clinical teams
  • Drive implementation of predictive models combining clinical, genetic, imaging, and circulating biomarkers to illuminate biological mechanisms and enable patient stratification and indication expansion.
  • Design, develop, and fine-tune large-scale neural network models, with a strong emphasis on language models.
  • Explore state-of-the-art techniques in NLP, transfer learning, and generative AI to enhance our capabilities.
  • Participate in and oversight of scientific report writing. Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Mentor junior members of the team and set goals, priorities and evaluation criteria for the team
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Experience and Qualifications

  • Ph.D. in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • 14 or more years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues.

The expected base pay range for this position is $225,000 – $325,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Associate Director, AI to report to the Executive Director, AI & Machine Learning and collaborate on development of deep neural networks (DNNs) and large language models (LLMs) leveraging multi-modal data (genetics, omics, EHR/text) to drive new insights and therapeutic hypotheses.  In this position, the individual will be responsible to build, train, test, and maintain predictive, interpretable, and generalizable data models. The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Key Duties and Responsibilities

  • Design, develop, and fine-tune large-scale neural network models, with a strong emphasis on language models.
  • Explore state-of-the-art techniques in NLP, transfer learning, and generative AI to enhance our capabilities.
  • Participate in and oversight of scientific report writing. Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Education and Experience

  • PhD in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • Minimum of 7 years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues.

The expected base pay range for this position is $125,000 – $240,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

 

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented Associate Director, Machine Learning to report to the Executive Director, Machine Learning and collaborate on development of statistical models leveraging multi-modal data (genetics, omics, EHR/text) to drive new insights and therapeutic hypotheses.  In this position, the individual will be responsible to build, train, test, and maintain predictive, interpretable, and generalizable data models. The position will be partnered cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Responsibilities

  • Design and perform analyses to infer causal mechanisms driving inflammatory mechanisms integrating data collected from pre-clinical models and human data sets.
  • Drive implementation of predictive models combining clinical, genetic, imaging, and circulating biomarkers to illuminate biological mechanisms and enable patient stratification and indication expansion.
  • Participate in and oversight of scientific report writing.Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group and project meetings).
  • Strong at building partnerships and working collaboratively with others to meet shared objectives.

Experience and Qualifications

  • PhD in Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • Minimum of 7 years of relevant biotech and/or pharmaceutical industry experience preferred.
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices.
  • Experience analyzing high-dimensional molecular data, such as imaging, video, or transcriptomics.
  • Experience leading a team of machine learning scientists to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Have a strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Can work in a highly interactive environment with a diverse team of colleagues. 

The expected base pay range for this position is $125,000 – $240,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Principal Scientist with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 8 years or more of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associates/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Director with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Experience and Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 12 or more years of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associate/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Associate Director with strong background in translational immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

Responsibilities

  • Lead or co-lead biological drug-discovery programs, with an emphasis in clinical lead generation.
  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development.
  • Analyze, critically interpret data and share results to project teams as required.
  • Keep meticulous records of experiments performed.
  • Act as a resource for other scientists in the group.

Experience and Qualifications

  • PhD, MD or equivalent post-graduate degree in Immunology or related field with 10 or more years of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in translational immunology is a plus.
  • Prior experience managing Associate/Scientists.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Hands-on lab experience in an industry drug discovery / development setting a plus.
  • Strong knowledge functional assay development, experience with preclinical animal models of autoimmune disease and ex-vivo models to assess immune responses in human (and other animal species) whole blood, PBMCs and various primary cell subsets required.
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues preferred as is hands-on experience using MSD, Luminex or ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required.
  • Proficient with MS office and standard data analysis packages (e.g. Prism, Flowjo, Systat).
  • Self-motivated with excellent problem-solving, organizational and communication skills.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a motivated, versatile, detail-oriented Senior Associate Scientist / Scientist to join the Immunology Translational Team. The focus will be on preclinical and IND-enabling in vitro studies. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment.

Key Duties and Responsibilities

  • Conceptualize and perform cell-based functional assays (cell lines, primary cells, whole blood) to support target validation, antibody drug screening, mechanism of action studies, biomarker identification and/or companion diagnostics development
  • Work on preclinical and IND-enabling in vitro studies
  • Analyze, critically interpret data and share results to project teams as required
  • Keep meticulous records of experiments performed and maintain ELN entries
  • Work collaborative with other scientists in the group in a highly matrixed lab environment

Education and Experience

  • Sr Associate Scientist requires: Bachelor’s degree with 6 or more years experience or Master’s degree with 2 or more years experience
  • Scientist requires: Bachelor’s degree with 8 or more years experience or Master’s degree with 6 or more years experience
  • Experience with molecular/ cell biology techniques such as CRISPR, RT-PCR, cell transfection, cell line generation are required
  • Experience using MSD, Luminex and ELISA to measure analytes in serum, plasma, supernatant or cell lysates is required
  • Experience developing ex-vivo models to assess immune responses from human whole blood, PBMCs, and various immune cell subsets.
  • Experience with cell-based assays including primary cell and reporter cell assays
  • Experience using multi-color flow cytometry to immunophenotype human cells from blood and tissues is required
  • Experience with Western Blots for samples generated from cell pellets and tissue
  • Experience with protein quantification techniques from tissue samples
  • Experience with tissue explants and organoid systems is a plus

Skills and Abilities

  • Independent self-motivated life scientist that can generate scientific questions and design experiments to address them
  • Energetic, curious and rigorous
  • Excellent problem-solving and organizational skills
  • Strong interpersonal and communication skills including presenting data to all levels of the organization
  • Scientific rigor and curiosity to address scientific questions and design experiments to test working hypothesis
  • Ability to work in fast-paced and matrix environment to meet project goals
  • Proficiency in data analysis using Excel, GraphPad Prism, Flow Jo is required

The expected base pay range for this position is $75,000 – $175,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a highly motivated protein engineer to join the biotherapeutics discovery group. The candidate must have demonstrable experience with antibody discovery and protein engineering programs in a biologics discovery setting.

Responsibilities

  • Expertise in protein and antibody engineering in the discovery and preclinical development of biotherapeutic candidates. Assist in evaluating new technologies to stay at the cutting edge of biologics discovery, production, and characterization.
  • Play a key role in assessing protein structure and function as applied toward the evaluation of biologics for protein design and engineering.
  • Present your findings and ideas to an interdisciplinary team with a wide range of technical backgrounds.

Qualifications

  • PhD in Molecular Biology, Structural Biology, Biophysics, Biochemistry, or related disciplines and 8 years or more of experience in the biotechnology or pharmaceutical industry
  • Manage all aspects of protein and antibody expression, purification, and characterization to support the preclinical discovery and development efforts of the biotherapeutics group.
  • Experience managing external CROs and vendors for protein engineering work.
  • Demonstrable experience in antibody discovery, antibody engineering, or the engineering of other proteins.
  • Familiarity with various antibody formats and scaffolds including, but not limited to fusion proteins, bi-specific antibodies, single-domain antibodies (VHH), and bi-paratopic antibodies.
  • Experience in mammalian cell culture and protein expression systems.
  • Self-starter, strong collaborative skills working in cross-functional teams and a start-up environment.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.  

Summary

We seek a motivated, detail-oriented Director, Discovery Immunology with strong background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

The role will require deep scientific and therapeutic-area expertise in Discovery Immunology, thorough familiarity and experience with the principles of drug development to ensure compound transition along the pipeline, management experience, and importantly the ability to work with ambiguity and embrace uncertainty. The role will demand critical, timely, independent decision making and requires a high degree of autonomy.

This leader must have scientific excellence in Immunology with a rich understanding of drug development, leadership, recruitment capabilities, management skills to direct a group of individuals, and excellent communication and collaboration skills to deliver on the therapeutic area strategy.

Qualifications

  • PhD or equivalent post-graduate degree in Immunology or related field with 12 years or more of experience in academia and industry, preferably in the field of auto-immune diseases.
  • Prior industry experience in Discovery Immunology required.
  • Prior people management experience.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Experience in early drug discovery with proven leadership of preclinical development of therapeutic project(s) and clinical candidate selection is a requirement.
  • Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards, and outstanding written and verbal communication skills.
  • A desire to be part of a highly innovative, dynamic, and growing company aimed at developing novel therapeutics for patients.
  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables, delivering clinical candidates into development.
  • Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators.
  • Proven track record of advancing programs through discovery, IND-enabling studies, and IND filing.
  • Ability to build strong relationships with key stakeholders.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a motivated, detail-oriented Principal Scientist/Associate Director, Discovery Immunology with strong background in immunology / cell biology and experience developing cell-based assays to support our efforts in target validation, early phase antibody drug discovery, IND-enabling studies, biomarker discovery and companion diagnostics development. The ideal candidate is an individual that enjoys a fast-paced and dynamic work environment, with a demonstrated ability to work collaboratively to support project goals and objectives.

The role will require deep scientific and therapeutic-area expertise in Discovery Immunology, thorough familiarity and experience with the principles of drug development to ensure compound transition along the pipeline, management experience, and importantly the ability to work with ambiguity and embrace uncertainty. The role will demand critical, timely, independent decision making and requires a high degree of autonomy.

This leader must have scientific excellence in Immunology with a rich understanding of drug development, leadership, recruitment capabilities, management skills to direct a group of individuals, and excellent communication and collaboration skills to deliver on the therapeutic area strategy.

Qualifications

  • Associate Director: PhD or equivalent post-graduate degree in Immunology or related field with 10 years or more of experience in academia and industry, preferably in the field of auto-immune diseases. Principal Scientist: PhD or equivalent post-graduate degree in Immunology or related field with 8 years or more of experience in academia and industry.
  • Prior industry experience in Discovery Immunology required.
  • Prior people management experience.
  • Prior experience leading project teams and managing CROs/vendors.
  • Direct experience working with immunology, inflammation and immune-mediated fibrotic diseases (Skin, Gut or Lung) or relevant molecular pathways.
  • Experience in early drug discovery with proven leadership of preclinical development of therapeutic project(s) and clinical candidate selection is a requirement.
  • Self-starter with strong scientific curiosity and rigor, excellent interpersonal and analytic skills, high ethical standards, and outstanding written and verbal communication skills.
  • A desire to be part of a highly innovative, dynamic, and growing company aimed at developing novel therapeutics for patients.
  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables, delivering clinical candidates into development.
  • Track record of developing efficient discovery processes and leading complex cross-functional team collaborations, including managing relationships with internal and external collaborators.
  • Proven track record of advancing programs through discovery, IND-enabling studies, and IND filing.
  • Ability to build strong relationships with key stakeholders.

The expected base pay range for this position is $150,000 – $225,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

 Summary
We are seeking a highly motivated hands-on physician leader to serve as Vice President, Clinical Development who will lead a portfolio of the company’s clinical studies for current and future indications.

This position will play a key role in driving the execution of studies from indication selection, protocol concept, design, and conduct, to final report including interpretation of clinical data, and preparation of documents for filing with regulatory agencies.

As a subject matter expert, the incumbent will work with key stakeholders on the development of clinical protocols to support the company’s product strategy, data collection and management, and final reports development in compliance with appropriate standard operating procedures, and regulatory and medical standards. This position interacts with various groups within the company and externally to the business to ensure alignment and oversee clinical research activities.

Responsibilities

  • Provide clinical leadership of trial execution from first-in-human through registrational studies.
  • Provide clinical leadership in the conduct of clinical activities including recruitment, data review, analysis, and reporting that conforms to the highest ethical, safety and quality standards and in compliance with GCP and regulatory standards.
  • Attend and present at investigator meetings and site initiation visits as applicable.
  • Provide clinical leadership in the preparation of Clinical Study Reports, Annual Reports and other safety reports, Health Authority pre-meeting packages, Investigator Brochures and other periodic clinical reports.
  • Collaborating with cross-functional groups to provide input in publication strategy including active participation in authoring, preparation, and review of manuscripts, conference abstracts and presentations, and other external presentations of clinical data.
  • Partner with R&D to provide clinical perspective to target selection and development strategy. Offer clinical input/direction on early-stage, pre-clinical projects.
  • Remain current on the therapeutic landscape in the relevant therapeutic areas through review of the scientific literature, interactions with key opinion leaders and other external experts, and attendance at relevant scientific meetings, in order to provide input and guidance for the strategic direction of the company.
  • Partner with Medical Affairs on the overall strategy for Target Product Profiles, clinical trial design, and ensuring dissemination of medically accurate information related to the company’s product candidates.

Qualifications

  • MD degree or equivalent is required. Board Certification or Board Eligibility in internal medicine, subspecialty training or experience in drug development in pulmonology, gastroenterology, or dermatology medicine is highly desirable.
  • 10 years or more of experience in pharmaceutical clinical drug development in industry including protocol development; study initiation and follow-up; IRB/EC submissions and interactions; review of clinical study data listings; review and/or preparation of clinical study reports.
  • The candidate should have experience with U.S. and European Health Authority interactions and have experience with submissions of clinical regulatory documents.
  • A clinical background that includes experience in pulmonology, gastroenterology, or dermatology a plus. Experience working across broad disease areas with an aptitude for learning equally desired.
  • Exceptional execution, and implementation of practices and initiatives to ensure timelines and budgets are met.
  • The ability to build and maintain excellent interpersonal relationships, both within and outside the company, at all levels.
  • A hands-on, entrepreneurial style with a sense of urgency, a bias toward action, comfort with calculated risk, and the ability to analyze situations rapidly and make prudent decisions.
  • Engaged, hands-on, independent, and goal-oriented mentality; willingness to work in a highly dynamic work environment and embrace uncertainty.

Skills and Abilities

  • Highly dynamic work environment and embrace uncertainty.
  • Ability to multi-task and willingness to flexibly contribute simultaneously in multiple facets of drug development; willingness to learn new therapeutic areas.
  • Self-motivated; strong commitment to follow up on tasks and action items; organizational, analytical, and problem-solving skills; risk identification and management; creative and innovative thinking all highly desirable.
  • Strong ability to work within and lead and motivate a cross-functional matrixed team.
  • The requisite scientific acumen and communication skills to influence and collaborate with key scientific, regulatory, and business leaders.
  • Sound strategic, clinical, technical, operational, and ethical judgment with uncompromising integrity.

The expected base pay range for this position is $250,000 – $400,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented computational scientist to combine multi-modal data (genetics, omics, imaging, EHR) to enable the development of new therapeutics. In this role, the successful candidate will design and apply computational methods to prioritize novel drug targets, enable patient enrichment strategies, and guide pre-clinical drug development decisions. A key focus of this role will be to leverage network and systems biology approaches to identify cell types, disease-specific pathways, and dysregulated pathways shared across subsets of immune-mediated diseases.

This position is based in San Diego, CA, may consider candidates outside of the area.

Responsibilities

  • Design and perform analyses to infer causal mechanisms driving immune-mediated and inflammatory mechanisms by integrating data collected from pre-clinical models and human data sets
  • Partner with Immunology and wider R&D organization to provide data-driven input on experimental design for target validation efforts (e.g., relevant conditions, assay read-outs, and/or appropriate genetic perturbations)
  • Connect therapeutic hypotheses to specific patient populations through network and pathway analysis of multi-omic datasets
  • Work with internal and external partners (in academia and industry) to collect functional data and develop integrative methods to empower future discovery efforts
  • Participate in and oversight of scientific report writing. Presentation of methods, results and conclusions to a publishable standard
  • Communicate findings in multiple settings (including 1:1, seminars, group and project meetings)

Education and Experience 

  • PhD in Computational Biology, Bioinformatics, Computer Science, Engineering, Statistics, or a related field required
  • Minimum of 6 years or more of experience in academia and industryfor Sr Scientist level; level based on skills, knowledge and experience
  • Minimum of 2 years of relevant industry experience
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices
  • Expertise in integration of multi-modal molecular data, such as genetics, multi-omics to reveal underlying pathways and networks involved in disease
  • Conceptual understanding of statistical genetics, GWAS/QTL integration, causal inference, and polygenic risk scores, and/or clinical genomics is a plus
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with biomarker and clinical trial data is a plus

 Skills and Abilities 

  • Demonstrated ability of contributing to and helping advance multi-disciplinary team projects
  • Track record of excellent interpersonal and communication skills, including ability to provide concise summaries of complex data to empower decision making
  • Strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward
  • Ability to work in a highly interactive environment with a diverse team of colleagues

The expected base pay range for this position is $100,000 -$175,000 (Sr Scientist – $125,000 – $200,000) plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We seek a talented computational scientist to combine multi-modal data (genetics, omics, imaging, EHR) to enable the development of new therapeutics. In this role, the successful candidate will design and apply computational methods to prioritize novel drug targets, enable patient enrichment strategies, and guide pre-clinical drug development decisions. A key focus of this role will be to design and execute integrative analyses that leverage cutting edge single cell-level assays including 10x, CyTOF, spatial-omics and CRIPR-seq screens to prioritize disease mechanisms, prioritize targets, and discriminate between disease subtypes.

This position is based in San Diego, CA, may consider candidates outside of the area.

Responsibilities

  • Design and perform analyses to infer causal mechanisms driving IBD and inflammatory mechanisms integrating data collected from pre-clinical models and human data sets
  • Partner with the immunology organization and wider R&D teams to provide data-driven input on experimental design for target validation efforts (e.g., relevant cell types, assay read-outs, and/or appropriate genetic perturbations)
  • Connect therapeutic hypotheses to specific patient populations through single cell or spatial omics profiling
  • Work with internal and external partners (in academia and industry) to collect functional data and develop integrative methods to empower future discovery efforts
  • Participate in and oversight of scientific report writing. Presentation of methods, results and conclusions to a publishable standard
  • Communicate findings in multiple settings (including 1:1, seminars, group and project meetings)

Education and Experience 

  • PhD in Genomics, Genetics, Bioinformatics, Computational Biology, Computer Science, Engineering, Statistics, or a related field required
  • Minimum of 6 years or more of experience in academia and industryfor Sr Scientist; level based on skills, knowledge and experience
  • Minimum of 2 years of relevant industry experience
  • Proficiency with at least one high-level programming language (R, Python, C/C++) for complex data analysis and reproducible research practices
  • Expertise in analysis of high-dimensional molecular data, such as single cell, spatial omics, CyTOF, CRISPR-Seq data and their applications
  • Conceptual understanding of statistical genetics, GWAS/QTL integration, causal inference, polygenic risk scores, and/or clinical genomics is a plus
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with biomarker and clinical trial data is a plus

Skills and Abilities 

  • Demonstrated ability of contributing to and helping advance multi-disciplinary team projects
  • Track record of excellent interpersonal and communication skills, including ability to provide concise summaries of complex data to empower decision making
  • Strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward
  • Ability to work in a highly interactive environment with a diverse team of colleagues

The expected base pay range for this position is $100,000 -$175,000 (Sr Scientist – $125,000 – $200,000) plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

Mirador provides equal employment opportunities to all employees and applicants for employment without regard to race, religion, religious creed (including religious dress and grooming practices), color, national origin, citizenship, ancestry, physical disability, mental disability, legally-protected medical condition or information (including genetic information), marital or domestic partner status, sex (including pregnancy, perceived pregnancy, childbirth, breastfeeding, or related medical conditions), gender, gender identity, gender expression, age (40 years and over), sexual orientation, military and/or veteran status, protected medical leaves (including but not limited to requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), requesting a reasonable accommodation on the basis of disability or bona fide religious belief or practice, victims of domestic violence, sexual assault, or stalking, political affiliation, and any other status protected by federal, state, or local law.

Equal employment opportunity applies to all terms and conditions of employment, including hiring, placement, promotion, discipline, termination, layoff, transfer, leave of absence, compensation, employee benefits and application of policies and training. It is the responsibility of every manager and employee to conscientiously follow this policy. Any employee having any questions regarding this policy should discuss them with Human Resources.

Thank you for your interest in Mirador Therapeutics and our recruitment opportunities. Recruiting and employment are managed through the Human Resources Department. Mirador requires that a signed agreement be in place prior to the presentation of any candidates. We ask that recruiters and agencies do not contact or solicit employees or managers in an attempt to present candidates. The company will not be obligated or responsible for any requested fees to candidate resumes that are unsolicited and or submitted to hiring managers without a written agreement signed by the Chief People Officer of Mirador. Thank you.