Together, we can accomplish more.

We are building a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360™ precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases.

We are led by a highly talented executive team with proven experience creating best places to work. We are driven to help patients in need, foster personal and professional growth, unlock our team potential, and to deliver exceptional results.

We offer competitive benefits, pay, time off, and perks!

If you have a passion for being a market leader, discovering and developing disruptive therapies, improving the lives of patients, love what you do and want to help us build a next-generation and best places to work company—we want to hear from you.

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Our Values

Mirador’s commitment to values of trust, ambition, collaboration, integrity, and excellence shapes our culture of teamwork, innovation, and relentless pursuit of developing transformative precision therapies for patients with immune-mediated diseases.

TRUST

  • We trust each other, believing that we all have best intentions and are delivering our part of the collective vision to improve the lives of patients with immune-mediated diseases.
  • We hold each other accountable, trusting that we have each other’s backs.
  • We trust in the process and feel empowered to address challenges knowing they are part of how we win.

AMBITION

  • We think creatively, experiment fearlessly, and develop groundbreaking ideas that benefit our patients.
  • Our ambition fuels our moonshot thinking and relentless pursuit of our goals.
  • We are empowered to challenge the status quo and seek new solutions to make what seems impossible a reality.

COLLABORATION

  • We show up every day knowing that every team member brings unique value and perspective to our shared vision.
  • We know that our team output is stronger than the sum of our individual capabilities.
  • We encourage active listening, open-mindedness, and constructive feedback across all levels of the organization.

INTEGRITY

  • We support each other to make the right decisions and do the right thing.
  • We have a commitment to ethical conduct in all aspects of our business.
  • Our truth is driven by science and data, which we follow no matter where it leads.

EXCELLENCE

  • We expect excellence in all we do.
  • We leverage diverse skills and perspectives to achieve excellence in our shared goals.
  • Individual excellence is a given; team excellence is our competitive advantage.

OWNERSHIP

  • We are invested in the success and reputation of our company, taking ownership in our work with care and commitment.
  • We take accountability as a team and as individuals to ensure the right outcomes.
  • We are writing the Mirador playbook together, collaborating, executing, and seeking continuous improvement across all levels of the organization.

Positions available at Mirador Therapeutics:

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary 

The Associate Director, Quantitative Clinical Pharmacology is responsible for the content and conduct of the Clinical Pharmacology studies as well as for all Clinical Pharmacology aspects of the clinical study protocols and clinical study reports. This position works collaboratively with involved functions and vendors/contract research organizations and consultants and is responsible for the timelines and budgets of the Clinical Pharmacology studies in collaboration with the Project Manager and relevant functions. May also be involved in business development activities and due diligences.

We are seeking a highly motivated individual to support our aggressive and innovative drug development pipeline. The incumbent will be supporting discovery, preclinical, and clinical drug development by providing pharmacokinetic and clinical pharmacology expertise across early and late development phases. The candidate will perform analysis of discovery pharmacology, animal toxicology, and clinical Phase I-III study data, and may represent the PK/CP department on cross-functional teams as needed. In addition, this position will support project teams with PK/PD M&S-based input to study design, evaluations, integrated data analysis, and reporting.

Responsibilities:

  • Leading quantitative and innovative strategies within Clinical Pharmacology to integrate MIDD during the life cycle of the program.
  • Develop Clinical Pharmacology study protocols in collaboration with all functions, vendors and consultants and selection of the appropriate Clinical Pharmacology vendors, including laboratories for pharmacokinetic analyses.
  • Input into Clinical Pharmacology sections of Investigator brochures, Clinical study protocols and reports, presentations, briefing documents, and submissions, in collaboration with all functions, vendors and consultants.
  • Planning Clinical Pharmacology aspects for development projects, including input into the development plans and Clinical Pharmacology support for Phase 1 through 3 studies.
  • Evaluate and apply state-of-the-art quantitative pharmacology approaches for clinical pharmacology decision-making and for global regulatory submissions, including INDs, IBs, NDAs, BLAs, MAAs, and pediatric plans in collaboration with key stakeholders.
  • Develop high-quality modeling and simulation strategy and content: author/review/approve modeling and simulation analysis plans and outputs, interpretation, and presentation of key findings to regulators and to stakeholders as needed.
  • Analysis of PK/PD data, both clinical and nonclinical, using sophisticated mathematical and statistical modeling and simulation tools to support dose selection, study design and proof-of-concept in early research, preclinical, and/or Clinical Development programs, including:
    • Translational PK/PD modeling for animal pharmacology/toxicology study design and FIH dose selection.
    • Population PK/PD modeling and exposure-response analyses supporting Phase 2/3 dosing and NDA submissions.
  • Prepare and update timelines and budgets of the Clinical Pharmacology studies in collaboration with the Project Manager and respective functions to ensure prompt and accurate execution of deliverables from Clinical Pharmacology studies and programs.
  • Author and review PK/PD modeling reports and PK-related sections of regulatory documents (e.g., study protocols and reports, IB, IND/IMPD, and NDA).
  • Involvement in internal process improvement activities such as SOPs or guidance documents, as assigned.
  • Opportunity to mentor Clinical Pharmacology fellows and interns.
  • Involvement in Business development activities and due diligences.

Education and Experience

  • Ph.D., PharmD, or MD with training in clinical pharmacology, PKPD, Pharmacology, and Pharmaceutical Sciences.
  • 7 or more years of experience in Clinical Pharmacology and drug development.
  • Experience in PK/PD modeling; including preclinical to clinical translation and population analyses.
  • Data manipulation, programming, and visualization skills and ideally with the use of programs such as R or similar programs.
  • Hands on experience in using pharmacometrics (PMx) tools and software (e.g., WinNonlin, NONMEM, and R) for individual (e.g., noncompartmental analysis, NCA) and population PK (PopPK) analysis, modeling, and simulations (M&S).
  • Familiarity of related disciplines (e.g., bioanalytics, biostatistics, toxicology, regulatory) in the drug development process.

Essential Skills and Abilities

  • Demonstrated ability to be a fast learner.
  • Demonstrated ability to be flexible and adaptable to change.
  • Recognized for sustained scientific excellence.
  • Extensive knowledge of quantitative analyses as well as the physiological/pharmacological aspects of drugs.
  • Thorough understanding of ICH Good Clinical Practices, Clinical Safety Data Management, clinical trials management (including protocol design, data management, site monitoring, statistical reporting, report writing), regulatory compliance and auditing including broad application of knowledge in different therapeutic areas.
  • Leadership capabilities for cross functional teams.
  • Good organizational, communication and presentation skills, including presentations to senior management and external audiences and experts.
  • Excellent written and oral communication skills with incredible attention to detail.
  • Ability to work on several projects and assignments at the same time and prioritize tasks.
  • A commitment to collaborative leadership, management, teamwork, delegation and foster a professional culture based on trust and mutual respect.
  • Up to 10% travel.

The expected base pay range for this position is $170,000 – $235,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a highly skilled and experienced Senior Bioinformatics Platform Engineer with a strong focus on data and software engineering to join our innovative bioinformatics team. In this hybrid role, you will lead the design, development, and optimization of computational platforms and data pipelines on Amazon Web Services (AWS). You will be at the forefront of integrating bioinformatics data engineering with software development practices, ensuring our platforms and tools are robust, scalable, and efficient for large-scale genomic and biological data analysis.

Responsibilities

  • Data Engineering Leadership: Lead the design and implementation of robust data pipelines for processing, storing, and analyzing large-scale genomic and biological datasets. Develop ETL processes to ensure efficient data flow and integration across platforms.
  • Software Development: Contribute to and lead the development of bioinformatics software tools and applications, ensuring they are well-integrated with data pipelines and platforms. Work closely with software engineering teams to apply best practices in software development, including version control, code review, testing, and documentation.
  • Cloud Infrastructure Management: Architect, build, and manage AWS cloud infrastructure using Infrastructure as Code (IaC) tools like Terraform or CloudFormation. Optimize AWS services (e.g., EC2, S3, Lambda, RDS, ECS/EKS) specifically for data-intensive bioinformatics workflows.
  • Performance Optimization: Monitor and enhance platform and pipeline performance, focusing on scalability, efficiency, and cost-effectiveness. Develop strategies for high availability, data redundancy, and disaster recovery.
  • Automation and CI/CD Pipelines: Develop and maintain automation scripts and CI/CD pipelines to streamline the deployment of software applications and data pipelines. Ensure that updates and new releases are managed efficiently and with minimal disruption to operations.
  • Data Security and Compliance: Implement and enforce data security best practices and ensure all platforms and pipelines comply with relevant regulations (e.g., HIPAA, GDPR) for handling sensitive genomic and clinical data.
  • Collaboration and Mentorship: Collaborate with bioinformaticians, data scientists, and other engineers to understand computational and data requirements. Mentor junior engineers and foster a culture of continuous learning and improvement within the team.
  • Documentation and Training: Maintain comprehensive documentation of platform architecture, data pipelines, and software development processes. Provide training and support to team members and stakeholders on platform and pipeline usage.

Education and Qualifications

  • Bachelor’s or Master’s degree in Bioinformatics, Computer Science, Computational Biology, Data Engineering, or a related field.
  • 5 years or more of experience in bioinformatics or computational biology, with a focus on cloud-based platforms and data engineering.
  • 5 years or more of experience in managing and optimizing AWS infrastructure, with a strong track record of using services like EC2, S3, Lambda, RDS, ECS/EKS, and VPC.
  • Proven experience with Infrastructure as Code (IaC) tools such as Terraform, CloudFormation, or AWS CDK.
  • Extensive experience in software development, including proficiency in Python, Java, or similar programming languages.
  • Strong background in data engineering, including designing ETL pipelines and working with large-scale biological datasets.
  • Certifications: AWS Certified Solutions Architect (Professional) or AWS Certified DevOps Engineer (Preferred).

Skills and Abilities

  • Deep understanding of bioinformatics tools, workflows, and data formats (e.g., FASTQ, BAM, VCF).
  • Expertise in data engineering tools and technologies, such as Apache Spark, Hadoop, and data lakes.
  • Proficiency in programming languages such as Python and R for data analysis and pipeline development.
  • Strong experience in Linux/Unix systems administration and shell scripting.
  • Experience with containerization and orchestration tools such as Docker and Kubernetes.
  • Strong experience with CI/CD tools and practices, such as Jenkins, GitLab CI, or AWS CodePipeline.
  • Familiarity with database management systems (SQL and NoSQL) and data warehousing solutions.
  • Knowledge of data security and compliance standards (HIPAA, GDPR) related to genomic data.
  • Strong analytical and problem-solving skills, with a proactive approach to identifying and solving technical challenges.
  • Excellent leadership and communication skills, with the ability to collaborate effectively with both technical and non-technical stakeholders.

The expected base pay range for this position is $125,000 – $195,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

#LI – remote

(San Diego, CA or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

Join our AI & Machine Learning team that develops and applies classical machine learning and deep learning models for different applications. We seek a talented individual to collaborate on development and application of deep neural networks (DNNs) and large language models (LLMs) leveraging multi-modal data (genetics, omics, EHR/text) to drive new insights and therapeutic hypotheses. In this position, the individual will be responsible to build, train, test, and maintain predictive, interpretable, and generalizable data models. The position will partner cross-functionally to align on standard assumptions and tools used to estimate future outcomes and build mechanisms that communicate to stakeholders when opportunities are identified.

Key Duties and Responsibilities

  • Explore state-of-the-art techniques in transfer learning and generative AI to enhance our capabilities.
  • Build applications and workflows on existing LLMs, and fine tune LLMs for specific tasks.
  • Design, develop, and deploy deep neural network models, evaluate and benchmark existing foundational models on custom data sets.
  • Participate in and oversight of scientific report writing. Presentation of methods, results, and conclusions to a publishable standard.
  • Communicate findings in multiple settings (including 1:1, group, and project meetings).

Education and Experience

  • Ph.D. in Bioinformatics, Computational Biology, Computer Science (concentration on machine learning/AI), Engineering, Statistics, or a related field
  • 2 years or more of relevant biotech and/or pharmaceutical industry experience or relevant academic experience.
  • Proficiency with at least one high-level programming language (R, Python, C++) for complex data analysis, deep learning libraries (pytorch, tensorflow), and reproducible research practices.
  • Experience with cloud computing and data platforms.
  • Experience analyzing high-dimensional molecular data, such as genetics, transcriptomics, imaging, video.
  • Experience working with a team of machine learning scientists and engineers to deliver on predefined key corporate objectives.
  • Background in inflammatory diseases (e.g., autoimmune diseases, IBD, and scleroderma) and/or experience working with clinical trial data is a plus.

Skills and Abilities

  • Demonstrated ability to contribute to and help advance multi-disciplinary team projects.
  • Track record of excellent interpersonal and communication skills, including providing concise summaries of complex data to empower decision-making.
  • Strong work ethic and are proactive in providing solutions to foster scientific collaborations and drive projects forward.
  • Ability to work in a highly interactive environment with a diverse team of colleagues.

The expected base pay range for this position is $100,000 – $160,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

#LI-remote

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA. 

Summary 

This position is responsible for the leadership, strategy and implementation of all aspects of biostatistics, programming, and data management across all clinical programs. Accountable for statistical design of clinical trials, statistical input and authoring of study protocols and statistical analysis plans, and execution and quality of statistical analyses. The position will require hands-on skills for statistical analysis and validation support to clinical projects and will oversee external vendors to ensure timely and accurate deliverables. This role will also provide statistical expertise for the development of biometrics standards and procedures. 

Responsibilities 

  • Lead statistical support to clinical programs, including strategic input to clinical development programs and regulatory interactions, accountable for statistical design and analysis of clinical studies and implementation of statistical analyses and TFLs. 
  • Oversight of programming and data management groups 
  • Collaborates with Clinical Development, Regulatory, Clinical Operations, and Data Management during the study setup and execution, including review of CRFs, IRT specs, UATs, data transfer agreements, DMC charter and statistical plan. 
  • Provide guidance and review of SDTM data sets, ADaM data sets, and Define.xml files along with all supporting documentation. 
  • Provide oversight to external vendors (e.g., CROs) and coordinate statistical and programming activities to meet quality standards and timelines. 
  • Provide hand-on statistical analysis and validation for statistical deliverables. 
  • Provide statistical consultation with Research, Bioinformatics, Clinical Pharmacology and Medical Affairs. 
  • Create biometrics-related SOPs, work practice documents, and technical standards, as appropriate. 

Experience and Qualifications 

  • Ph.D. in Statistics, Biostatistics or related discipline with 15 or more years of experience leading biostatistics function for phase I-IV clinical trials in biotech, pharmaceutical industry and/or CRO environment. 
  • Experience building a team of Biostatisticians, Programmers and Data Management 
  • Technical knowledge and experience with experimental design, advanced statistical analysis methodology, and simulation. 
  • Technical knowledge and experience with SDTM, ADaM, and Define.XML. 

Skills and Abilities 

  • Strong understanding of the drug development process, regulatory guidance, submission-related activities and regulatory requirements (e.g., CDISC, CDASH, eCTD) and guidelines (e.g., ICH, CHMP, FDA, GCP). 
  • Strong knowledge of SAS functionalities (including ODS, SQL, MACRO, STAT, GRAPH, and ACCESS) and experience with MS Office are required. Familiarity or experience with R Software is a plus. 
  • Ability to effectively communicate and perform in a high demand and dynamic working environment. 
  • Well organized with the ability to multitask, prioritize, and manage complexity and shifting responsibilities in a dynamic, collaborative, cross-functional teamwork environment. 
  • Must have strong interpersonal and organizational skills and excellent verbal and written communication skills. 

The expected base pay range for this position is $275,000 – $325,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future. 

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class. 

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a strategic and technical leader to build and lead both the biologics and small molecule analytical development and QC function in support of our innovative, fast-growing pipeline of novel therapies. The ideal candidate will be able to apply state-of-the-art analytical method development, product characterization and quality control for biologics, including ADCs, and small molecules across the drug development phases. The ideal candidate must have demonstrated analytical & QC experience across regulatory regions in establishing accepted product control strategies from pre-clinical to commercialization.

Responsibilities

  • Lead and oversee the analytical development & QC function in developing robust phase-appropriate analytical methods for characterization and release of intermediates, active pharmaceutical ingredients, and drug product candidates in the pipeline.
  • Build a high performing analytical/QC function within CMC to support clinical development and commercialization of large and small molecule programs.
  • Assist in the selection of CDMOs and contract laboratories for non-GMP/GMP development and manufacturing.
  • Lead and oversee analytical development in designing and developing robust phase-appropriate analytical methods for characterization and routine testing of materials.
  • Collaborate with cross-functional teams, including QA and Regulatory, to ensure alignment of analytical methods and controls with overall project goals.
  • Execute the overall analytical development control strategy throughout development with robust analytical and biological methods for the characterization of starting materials, intermediates, products, and known/potential impurities.
  • Enable product characterization capabilities across vendors to demonstrate product understanding and comparability through development life cycle.
  • Guide critical quality attribute, specification, and control strategy development.
  • Ensure phase appropriate method qualification and testing activities for biologic/small molecule products are available at qualified vendors.
  • Manage investigational testing and assist with deviations/investigations/CAPA’s as they pertain to both internal and external (CDMOs) quality management systems.
  • Implement and maintain analytical testing procedures in compliance with regulatory requirements based on relevant guidance and accepted standard organizations (e.g., USP, EP, JP, etc.).
  • Expertise in developing and validating both biologic and small molecule analytical methods early and late-stage products in development.
  • Oversee all analytical based activities at CDMOs by providing analytical development and testing guidance to ensure all analytical methodologies are robust and in compliance.
  • Develop team members, both internally and at selected partners, to continually improve their technical capabilities.
  • In conjunction with other CMC members and QA, communicate product quality risks at all stages of development.
  • Complete projects within established timelines, resource constraints and regulatory requirements.
  • Work closely with regulatory CMC to ensure that analytical methods and specifications meet all regulatory guidelines and are properly represented in regulatory filings.
  • Author/review regulatory submissions to include all relevant analytical data and documentation in support of clinical/commercial products.

Experience and Qualifications

  • Ph.D. in Analytical Chemistry, Pharmaceutical Sciences, or a related field.
  • 12 years or more of biotech or pharmaceutical industry experience leading analytical development and QC of both large and small molecules within a CMC department with at 6 years or more in a leadership position.

Essential Skills and Abilities

  • Excellent leadership, communication, and project management skills.
  • Demonstrated leadership of analytical development and QC teams both internally and externally.
  • Generate and analyze data to guide critical decision making within CMC which could include the use of statistical analysis and data mining for quality trending.
  • Knowledgeable on current regulatory requirements and industry practices in the analytical development and QC functions.
  • Excellent verbal and written communication skills with the ability to communicate with vendors, internal teams (including management), and regulators.
  • Flexible and “hands-on” to navigate between strategic and technical roles.
  • Able to work in a fast-paced bio-tech environment while managing multiple projects.
  • Attend teleconferences/meetings during non-core hours based on the location of vendors including the ability to travel ≥25%.

The expected base pay range for this position is $200,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

We are seeking a highly motivated protein engineer scientist to join the biotherapeutics discovery group. The candidate must have demonstrable experience with antibody discovery and protein engineering programs in a biologics discovery setting.

Responsibilities

  • Expertise in protein and antibody engineering in the discovery and preclinical development of biotherapeutic candidates. Assist in evaluating new technologies to stay at the cutting edge of biologics discovery, production, and characterization.
  • Play a key role in assessing protein structure and function as applied toward the evaluation of biologics for protein design and engineering.
  • Present your findings and ideas to an interdisciplinary team with a wide range of technical backgrounds.

Qualifications

  • Bachelor’s degree with 8 or more years experience or Master’s degree with 6 or more years experience or PhD and 2 years or more of experience in the biotechnology or pharmaceutical industry
  • Manage protein and antibody expression, purification, and characterization to support the preclinical discovery and development efforts of the biotherapeutics group.
  • Experience coordinating with and managing external CROs and vendors for protein engineering work.
  • Demonstrable experience in antibody discovery, antibody engineering, or the engineering of other proteins.
  • Familiarity with various antibody formats and scaffolds including, but not limited to fusion proteins, bi-specific antibodies, single-domain antibodies (VHH), and bi-paratopic antibodies.
  • Experience in mammalian cell culture and protein expression systems (Expi 293).
  • Experience in molecular biology (Gibson assembly), protein purification (FPLC), protein QC (HPLC), and protein binding kinetics (SPR)
  • Self-starter, strong collaborative skills working in cross-functional teams and a start-up environment.

The expected base pay range for this position is $100,000 – $165,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(San Diego, CA preferred or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

The Director, CMC will lead biologics development and manufacturing to deliver clinical trial supplies across multiple clinical studies.

Responsible for directing technical aspects of the biologics process development and manufacturing activities at contract manufacturers organizations (CMOs) and consultants including development, scale-up, technical transfers, validation, delivery of launch supplies.  Daily activities such as on-going manufacturing support, process improvements, analytical development determination and development, and technical guidance both internally and externally.  Responsible for coordinating manufacturing, packaging and distribution of clinical trial materials and set up of drug distribution through IVRS/IWRS.

Support the CMC team in writing Quality sections for global regulatory filings and also provide support of business development activities and due diligences.

Responsibilities

  • Responsible for leading and overseeing all aspects of the manufacture of products at CROs and/or CMOs around the world and ensures adherence to project timelines to support clinical and/or commercial supply in line with business objectives.
  • Reviews and provides oversight of all documentation related to the production of the product including but not limited to:development, scale-up and validation protocols/reports batch records, deviations, process excursions, analytical methods, protocols and reports.
  • Contributes in setting up specifications for starting materials, intermediates and drug substance and product.In conjunction with the CMO and other groups adjudicates deviations and leads or conducts a root cause analysis and implement proposed corrective actions at CRO/CMO.

Experience and Qualifications

  • Ph.D. highly preferred with a minimum of 10 years of experience in biologics development, pilot plant, biologics development and manufacturing operations for pharmaceutical APIs (drug substances).
  • Bachelor’s or Master’s degree in Biology, Microbiology, Chemical Engineering or related field with a minimum of 12 years of experience.
  • Demonstrated scientific knowledge relevant to development and manufacture of biologic drug substances and products with understanding of analytical techniques required for phase appropriate development.
  • Must have demonstrated experience in managing and influencing diverse project activities with third party manufacturing facilities at different geographical locations.
  • Strong project management experience with cross-functional team leadership and participation skills.
  • Requires strong understanding of technology transfer; cGMPs, FDA, EU, ICH guidelines; as well as CMC content of regulatory submissions.

Essential Skills and Abilities

  • Self-starter who can work independently and can prioritize tasks.
  • Strong communication skills, (both written and oral) including presentations to senior management and external audiences and experts.
  • Strong understanding and working knowledge of cGMPs for biologics pharmaceutical development and operations.
  • Leadership capabilities for cross functional teams.
  • Ability to work across locations and time zones; must be able to travel approximately 25% including international travel.

The expected base pay range for this position is $175,000 – $275,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

(an Diego, CA preferred or remote)

Mirador is a next-generation precision medicine company focused on immunology and inflammation. The company’s Mirador360 TM precision development engine leverages the latest advances in human genetics and cutting-edge data science to rapidly advance new precision medicines for patients living with chronic immune-mediated inflammatory and fibrotic diseases. Launched in 2024, Mirador has raised over $400 million from leading life sciences investors and is based in San Diego, CA.

Summary

As Scientific Data Curation Engineer you will drive the delivery of high-quality clinical and omic datasets to the world-class Mirador360 platform to accelerate the work of Mirador’s Precision Analytics team. The Scientific Data Engineer conducts acquisition and disposition activities related to biomedical data collected from various sources, in diverse formats, and using different modalities.  You will support the specification, acquisition, organization, QC, annotation, and harmonization of data using specified standards and ensure data are stored in defined locations within system.  You will drive execution and adhere to timelines for both vendor-managed and hands-on data curation projects.  As the company’s data curation expert, you will act as a liaison and consultant on best practices, principles and processes required to leverage best in class data curation capabilities and technologies.

Responsibilities

  • Clean, harmonize, curate and catalog clinical, omics, and other data and metadata according to various data practices and standards
  • Align data to ontologies/vocabularies
  • Collaborate with cross-functional team members to define and implement new data standards, data models, terminologies, and ontologies and to provide input on automated omics processing pipelines
  • Collaborate with cross-functional team members to plan which data will be loaded for what purpose and define the required quality control steps
  • Engage data providers to manage acquisition of electronic datasets
  • Understand the context underlying each data type targeted for acquisition to ensure that the data quality is fit for purpose
  • Support the development and documentation of metadata standards for sharing datasets under the Findability Accessibility Interoperability and Reusability (FAIR) guiding principles
  • Streamline data curation processes and implement new methods and pipelines
  • Assess transferred data for quality and conformance and resolve any queries/issues with data provider
  • Work with team members in the development and implementation of data standards and processes to ensure data quality
  • Communicate strategies, ideas, goals, and progress to the team
  • Collaborate closely with Precision Analytics team

Experience and Qualifications

  • Master’s degree with at least 3 years experience OR a Bachelor’s degree with at least 5 years experience in the data science field in biotech, diagnostics or pharma industry experience
  • Experience organizing, analyzing and visualizing common biomedical data types derived from disease model systems and patients
  • Experience with genetics, gene expression and other omic data is preferred
  • Experience in a scripting language (e.g. bash, R or python)
  • Experience working with external vendors and internal stakeholders to refine deliverables and timelines along organizational priorities
  • Knowledge of CDISC data standards, ICH-GCP, Awareness of Patient-level Data Access principles, and experience in regulated environments
  • Knowledge of basic biological principles and the pharmaceutical development process (including clinical trials, patient level datasets and study documentation)
  • Deep understanding of clinical and omics data, data curation methodologies, and a commitment to maintaining data accuracy and integrity
  • Systematic, structured, and pragmatic approach to tasks, with good attention to detail
  • Ability to effectively manage multiple requests and priorities

Essential Skills and Abilities

  • Clear and proactive communication skills and the ability to communicate appropriately with corporate executives, technical and non-technical teams
  • Strong influencing and reasoning skills; good at conflict resolution and consensus building
  • Self-motivated and collaborative with excellent planning, independent problem-solving and organizational skills
  • Ability to engage constructively with peers and technical leads to communicate the technical approach, trade-offs, and technical decisions
  • Entrepreneurial, thrives in a fast-paced, smaller-company environment

The expected base pay range for this position is $100,000 -$175,000 plus bonus, equity, and comprehensive benefits. The base pay range reflects the target range for this position, but individual pay will be determined by additional factors such as job-related skills, experience and relevant education or training. This range may be modified in the future.

All qualified applicants are considered for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity, national origin, disability, veteran status or other protected class.

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Mirador provides equal employment opportunities to all employees and applicants for employment without regard to race, religion, religious creed (including religious dress and grooming practices), color, national origin, citizenship, ancestry, physical disability, mental disability, legally-protected medical condition or information (including genetic information), marital or domestic partner status, sex (including pregnancy, perceived pregnancy, childbirth, breastfeeding, or related medical conditions), gender, gender identity, gender expression, age (40 years and over), sexual orientation, military and/or veteran status, protected medical leaves (including but not limited to requesting or approved for leave under the Family and Medical Leave Act or the California Family Rights Act), requesting a reasonable accommodation on the basis of disability or bona fide religious belief or practice, victims of domestic violence, sexual assault, or stalking, political affiliation, and any other status protected by federal, state, or local law.

Equal employment opportunity applies to all terms and conditions of employment, including hiring, placement, promotion, discipline, termination, layoff, transfer, leave of absence, compensation, employee benefits and application of policies and training. It is the responsibility of every manager and employee to conscientiously follow this policy. Any employee having any questions regarding this policy should discuss them with Human Resources.

Thank you for your interest in Mirador Therapeutics and our recruitment opportunities. Recruiting and employment are managed through the Human Resources Department. Mirador requires that a signed agreement be in place prior to the presentation of any candidates. We ask that recruiters and agencies do not contact or solicit employees or managers in an attempt to present candidates. The company will not be obligated or responsible for any requested fees to candidate resumes that are unsolicited and or submitted to hiring managers without a written agreement signed by the Chief People Officer of Mirador. Thank you.